This article has been cited by other articles in PMC. Abstract Cancer patients undergoing chemotherapy treatment are advised to increase food intake to overcome the therapy-induced side effects, and weight loss.
Print In vitro and in vivo data suggest that selective amino acid deprivation may have anticancer activity. Controlled amino acid therapy CAAT is a protocol developed for patients with cancer that includes strict dietary guidelines and nutritional supplements that focus on controlling amino acid and carbohydrate intake.
John Institute for Cancer Research and is touted to be based on extensive clinical research, but studies in humans or animal models of the entire CAAT protocol have not been published, nor have results — case studies or observational studies — from the institute been published.
The exact protocol is not reported and the website for the institute is no longer functioning. Components of the protocol, such as selective amino acid restriction, and supplements such as vitamin D and antioxidants, have been studied separately in vitro and in some animal models.
This fact sheet focuses on the amino acid deprivation component. Continue Reading Below Selective Amino Acid Deprivation A major component of CAAT is selective amino acid restriction therapy SAARTwhich is based on the hypothesis that many cancer cells develop mutations that prevent the synthesis of some amino acids that are required for protein synthesis and thus continued cell survival.
When these cancer cells are deprived of an exogenous source of these amino acids, the cell cannot perform protein synthesis and thus is unable to survive.
This hypothesis has not, however, been fully tested in vivo, but is based on observations from studies of single amino acid deprivation and overall protein restriction in vitro and in vivo.Zinc is the second most abundant metal in organisms (second only to iron), with grams distributed throughout the human body.
Most zinc is found in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and parts of the eye. Cycles of starvation (fasting) were as effective as chemotherapeutic agents in delaying progression of specific tumors and increased the effectiveness of these .
Apr 27, · Decreased protein intake also inhibited tumor growth, but did not affect body weight, in a xenograft mouse model of human breast cancer.
4 Several studies also . In cancer cells, glucose starvation activates a metabolic and signaling feedback loop leading to cell death. Glucose starvation induces generation of reactive oxygen species generation (ROS.
Animal studies show that dietary restriction can have many health benefits, but how best to apply such diets in people is still under study. NastjaPungracic\iStock\Thinkstock Dietary restriction has been shown in a variety of animal models to have many health benefits.
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Biomed Central.
Dietary Interventions, Cardiovascular Aging, and Disease Animal Models and Human Studies. Circulation Research.
May Dietary Interventions, Cardiovascular Aging, and Disease Animal Models and Human Studies Starvation-dependent.